4x damage combo on Flagship. Glass Cannon gives all weapons on board 2x damage while Big Guns gives all of our large items 2x damage. A single Flagship activation should do over 5,000 damage.
We combo Flurry of Blows (when you use a weapon, charge a weapon 1 second) with the fast attacks from Turbo Double Barrel by only having 2 items with activations on board.